2021 Big 12 Conference Leaders All Purpose - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Trestan Ebner | Baylor | SR | RB | 11 | 459 | 213 | 176 | 456 | 165 | 1304 | 7.9 | 118.5 |
| 2 | Kwamie Lassiter II | Kansas | SR | WR | 10 | 0 | 556 | 108 | 0 | 58 | 664 | 11.4 | 66.4 |
| 3 | D'Shawn Jamison | Texas | SR | DB | 10 | 0 | 0 | 88 | 399 | 29 | 502 | 17.3 | 50.2 |
| 4 | Phillip Brooks | Kansas St | JR | WR | 11 | -10 | 494 | 84 | 31 | 50 | 599 | 12.0 | 54.5 |
| 5 | Derius Davis | TCU | SR | WR | 10 | 42 | 444 | 69 | 473 | 66 | 1028 | 15.6 | 102.8 |
| 5 | Jaylin Noel | Iowa State | FR | WR | 11 | 0 | 255 | 69 | 286 | 57 | 610 | 10.7 | 55.5 |
| 7 | Isaiah Esdale | WVU | SR | WR | 9 | -7 | 334 | 57 | 0 | 41 | 384 | 9.4 | 42.7 |
| 8 | Adrian Frye | Texas Tech | SR | DB | 7 | 0 | 0 | 47 | 0 | 8 | 47 | 5.9 | 6.7 |
| 9 | Marvin Mims | Oklahoma | SO | WR | 11 | 15 | 569 | 46 | 51 | 37 | 681 | 18.4 | 61.9 |
| 10 | Myles Price | Texas Tech | SO | WR | 9 | 80 | 487 | 27 | 0 | 44 | 594 | 13.5 | 66.0 |
| 11 | Brennan Presley | Okla St | SO | WR | 10 | 35 | 357 | 17 | 330 | 54 | 739 | 13.7 | 73.9 |
| 11 | DeMarvion Overshown | Texas | SR | LB | 9 | 0 | 0 | 17 | 0 | 1 | 17 | 17.0 | 1.9 |
| 13 | McLane Mannix | Texas Tech | SR | WR | 9 | 17 | 99 | 13 | 0 | 9 | 129 | 14.3 | 14.3 |
| 14 | Tarique Milton | Iowa State | SR | WR | 10 | 0 | 242 | 11 | 0 | 12 | 253 | 21.1 | 25.3 |
| 15 | Ty Bowman | Kansas St | FR | WR | 8 | 0 | 0 | 9 | 0 | 1 | 9 | 9.0 | 1.1 |
| 16 | Darien Porter | Iowa State | SO | WR | 11 | 0 | 0 | 8 | 0 | 1 | 8 | 8.0 | 0.7 |
| 17 | Marcus Washington | Texas | JR | WR | 10 | 0 | 276 | 5 | 0 | 18 | 281 | 15.6 | 28.1 |
| 18 | Jaden Nixon | Okla St | FR | RB | 2 | 122 | 3 | 2 | 15 | 17 | 142 | 8.4 | 71.0 |