2021 Big 12 Conference Leaders All Purpose - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derius Davis | TCU | SR | WR | 5 | -15 | 169 | 51 | 280 | 30 | 485 | 16.2 | 97.0 |
| 2 | Isaiah Esdale | WVU | SR | WR | 4 | 0 | 233 | 31 | 0 | 22 | 264 | 12.0 | 66.0 |
| 3 | Myles Price | Texas Tech | SO | WR | 5 | 56 | 166 | 27 | 0 | 23 | 249 | 10.8 | 49.8 |
| 4 | Kwamie Lassiter II | Kansas | SR | WR | 4 | 0 | 147 | 24 | 0 | 16 | 171 | 10.7 | 42.8 |
| 5 | Trestan Ebner | Baylor | SR | RB | 4 | 214 | 7 | 23 | 186 | 57 | 430 | 7.5 | 107.5 |
| 6 | Jaylin Noel | Iowa State | FR | WR | 4 | 0 | 76 | 17 | 109 | 16 | 202 | 12.6 | 50.5 |
| 6 | DeMarvion Overshown | Texas | SR | LB | 4 | 0 | 0 | 17 | 0 | 1 | 17 | 17.0 | 4.3 |
| 8 | Marvin Mims | Oklahoma | SO | WR | 5 | 0 | 412 | 16 | 20 | 19 | 448 | 23.6 | 89.6 |
| 9 | D'Shawn Jamison | Texas | SR | DB | 4 | 0 | 0 | 14 | 165 | 12 | 194 | 16.2 | 48.5 |
| 10 | McLane Mannix | Texas Tech | SR | WR | 5 | 16 | 26 | 13 | 0 | 5 | 55 | 11.0 | 11.0 |
| 11 | Brennan Presley | Okla St | SO | WR | 4 | 31 | 130 | 7 | 67 | 23 | 235 | 10.2 | 58.8 |
| 12 | Phillip Brooks | Kansas St | JR | WR | 4 | 0 | 200 | 4 | 0 | 17 | 204 | 12.0 | 51.0 |
| 13 | Jaden Nixon | Okla St | FR | RB | 1 | 53 | 3 | 2 | 15 | 14 | 73 | 5.2 | 73.0 |