2021 Big 12 Conference Leaders All Purpose - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jaylin Noel | Iowa State | FR | WR | 5 | 0 | 117 | 51 | 78 | 27 | 246 | 9.1 | 49.2 |
| 2 | Derius Davis | TCU | SR | WR | 3 | 8 | 94 | 29 | 195 | 21 | 326 | 15.5 | 108.7 |
| 2 | Trestan Ebner | Baylor | SR | RB | 5 | 189 | 62 | 29 | 190 | 68 | 470 | 6.9 | 94.0 |
| 4 | Marvin Mims | Oklahoma | SO | WR | 3 | 15 | 78 | 28 | 0 | 9 | 121 | 13.4 | 40.3 |
| 5 | D'Shawn Jamison | Texas | SR | DB | 5 | 0 | 0 | 20 | 152 | 13 | 172 | 13.2 | 34.4 |
| 6 | Xavier Worthy | Texas | FR | WR | 5 | 7 | 479 | 18 | 18 | 24 | 522 | 21.8 | 104.4 |
| 7 | DeMarvion Overshown | Texas | SR | LB | 5 | 0 | 0 | 17 | 0 | 1 | 17 | 17.0 | 3.4 |
| 8 | McLane Mannix | Texas Tech | SR | WR | 4 | 1 | 73 | 16 | 0 | 6 | 90 | 15.0 | 22.5 |
| 9 | Tarique Milton | Iowa State | SR | WR | 4 | 0 | 62 | 11 | 0 | 6 | 73 | 12.2 | 18.3 |
| 10 | Isaiah Esdale | WVU | SR | WR | 2 | 0 | 49 | 8 | 0 | 7 | 57 | 8.1 | 28.5 |
| 11 | Adrian Frye | Texas Tech | SR | DB | 3 | 0 | 0 | 5 | 0 | 5 | 5 | 1.0 | 1.7 |