2021 Big 12 Conference Leaders All Purpose - Games on the Road/Neutral Site Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush | Recv. | Punt Ret. | Kick Ret. | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Trestan Ebner | Baylor | SR | RB | 7 | 350 | 48 | 98 | 225 | 106 | 721 | 6.8 | 103.0 |
| 2 | Jaylin Noel | Iowa State | FR | WR | 7 | 0 | 218 | 74 | 155 | 42 | 447 | 10.6 | 63.9 |
| 3 | Phillip Brooks | Kansas St | JR | WR | 6 | -10 | 246 | 72 | 31 | 27 | 339 | 12.6 | 56.5 |
| 4 | Kwamie Lassiter II | Kansas | SR | WR | 6 | 0 | 388 | 61 | 0 | 38 | 449 | 11.8 | 74.8 |
| 5 | Derius Davis | TCU | SR | WR | 5 | 4 | 196 | 49 | 362 | 34 | 611 | 18.0 | 122.2 |
| 6 | Marvin Mims | Oklahoma | SO | WR | 6 | 15 | 299 | 44 | 0 | 20 | 358 | 17.9 | 59.7 |
| 7 | McLane Mannix | Texas Tech | SR | WR | 6 | 17 | 83 | 29 | 0 | 10 | 129 | 12.9 | 21.5 |
| 8 | DeMarvion Overshown | Texas | SR | LB | 6 | 0 | 0 | 17 | 0 | 1 | 17 | 17.0 | 2.8 |
| 9 | D'Shawn Jamison | Texas | SR | DB | 6 | 0 | 0 | 14 | 225 | 15 | 254 | 16.9 | 42.3 |
| 10 | Isaiah Esdale | WVU | SR | WR | 5 | 0 | 101 | 7 | 0 | 14 | 108 | 7.7 | 21.6 |
| 11 | Adrian Frye | Texas Tech | SR | DB | 5 | 0 | 0 | 5 | 0 | 5 | 5 | 1.0 | 1.0 |
| 12 | Brennan Presley | Okla St | SO | WR | 7 | 22 | 330 | 1 | 120 | 42 | 473 | 11.3 | 67.6 |