2021 Conference USA Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 1 | 72 | 488 | 91 | 560 | 6.15 | 560.0 |
| 2 | Louisiana Tech | 1 | 139 | 341 | 79 | 480 | 6.08 | 480.0 |
| 3 | UTSA | 1 | 117 | 255 | 62 | 372 | 6.00 | 372.0 |
| 4 | UAB | 2 | 350 | 236 | 119 | 586 | 4.92 | 293.0 |
| 5 | Marshall | 1 | 187 | 99 | 56 | 286 | 5.11 | 286.0 |
| 6 | Old Dominion | 1 | 145 | 127 | 77 | 272 | 3.53 | 272.0 |
| 7 | Rice | 2 | 207 | 313 | 129 | 520 | 4.03 | 260.0 |
| 8 | Southern Mississippi | 1 | 82 | 131 | 57 | 213 | 3.74 | 213.0 |