2021 Conference USA Leaders Total Offense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 7 | 695 | 3054 | 545 | 3749 | 6.88 | 535.6 |
| 2 | UTSA | 6 | 1116 | 1765 | 457 | 2881 | 6.30 | 480.2 |
| 3 | Marshall | 6 | 859 | 1554 | 414 | 2413 | 5.83 | 402.2 |
| 4 | North Texas | 7 | 1377 | 1413 | 570 | 2790 | 4.89 | 398.6 |
| 5 | Louisiana Tech | 6 | 676 | 1681 | 416 | 2357 | 5.67 | 392.8 |
| 6 | Charlotte | 4 | 644 | 871 | 284 | 1515 | 5.33 | 378.8 |
| 7 | UTEP | 4 | 428 | 986 | 250 | 1414 | 5.66 | 353.5 |
| 8 | UAB | 6 | 1051 | 1000 | 369 | 2051 | 5.56 | 341.8 |
| 9 | Florida Atlantic | 6 | 669 | 1261 | 416 | 1930 | 4.64 | 321.7 |
| 10 | Middle Tennessee | 5 | 534 | 1028 | 354 | 1562 | 4.41 | 312.4 |
| 11 | Rice | 6 | 698 | 1164 | 408 | 1862 | 4.56 | 310.3 |
| 12 | Old Dominion | 7 | 798 | 1305 | 455 | 2103 | 4.62 | 300.4 |
| 13 | Florida International | 5 | 300 | 1116 | 317 | 1416 | 4.47 | 283.2 |
| 14 | Southern Mississippi | 5 | 359 | 638 | 307 | 997 | 3.25 | 199.4 |