2021 Conference USA Leaders Total Offense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Marshall | 4 | 675 | 1529 | 300 | 2204 | 7.35 | 551.0 |
| 2 | Western Kentucky | 3 | 244 | 1278 | 184 | 1522 | 8.27 | 507.3 |
| 3 | UTSA | 4 | 703 | 1072 | 324 | 1775 | 5.48 | 443.8 |
| 4 | Charlotte | 4 | 782 | 989 | 284 | 1771 | 6.24 | 442.8 |
| 5 | Florida International | 4 | 556 | 1121 | 249 | 1677 | 6.73 | 419.3 |
| 6 | Florida Atlantic | 4 | 675 | 972 | 291 | 1647 | 5.66 | 411.8 |
| 7 | UTEP | 4 | 657 | 957 | 264 | 1614 | 6.11 | 403.5 |
| 8 | North Texas | 4 | 832 | 757 | 336 | 1589 | 4.73 | 397.3 |
| 9 | Louisiana Tech | 4 | 511 | 1076 | 269 | 1587 | 5.90 | 396.8 |
| 10 | UAB | 4 | 640 | 891 | 253 | 1531 | 6.05 | 382.8 |
| 11 | Old Dominion | 4 | 776 | 696 | 307 | 1472 | 4.79 | 368.0 |
| 12 | Rice | 4 | 700 | 712 | 260 | 1412 | 5.43 | 353.0 |
| 13 | Middle Tennessee | 4 | 293 | 1101 | 254 | 1394 | 5.49 | 348.5 |
| 14 | Southern Mississippi | 4 | 496 | 570 | 270 | 1066 | 3.95 | 266.5 |