2018 Atlantic Coast Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/07/2019
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina | 1 | 140 | 406 | 85 | 546 | 6.42 | 546.0 |
| 2 | Miami (Florida) | 1 | 156 | 140 | 65 | 296 | 4.55 | 296.0 |
| 3 | Boston College | 2 | 337 | 657 | 164 | 994 | 6.06 | 497.0 |
| 4 | Clemson | 4 | 368 | 1135 | 281 | 1503 | 5.35 | 375.8 |
| 5 | Virginia Tech | 2 | 423 | 477 | 135 | 900 | 6.67 | 450.0 |
| 6 | Duke | 3 | 475 | 730 | 231 | 1205 | 5.22 | 401.7 |
| 7 | Georgia Tech | 2 | 533 | 394 | 127 | 927 | 7.30 | 463.5 |
| 8 | North Carolina State | 3 | 573 | 1000 | 219 | 1573 | 7.18 | 524.3 |
| 9 | Syracuse | 3 | 610 | 745 | 230 | 1355 | 5.89 | 451.7 |
| 10 | Wake Forest | 3 | 976 | 709 | 241 | 1685 | 6.99 | 561.7 |
| 11 | Florida State | 4 | 989 | 1007 | 319 | 1996 | 6.26 | 499.0 |
| 12 | Pittsburgh | 5 | 1009 | 1084 | 352 | 2093 | 5.95 | 418.6 |
| 13 | Louisville | 4 | 1380 | 919 | 277 | 2299 | 8.30 | 574.8 |