2016 Atlantic Coast Conference Leaders Total Defense - Games in August/September Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 3 | 327 | 607 | 182 | 934 | 5.13 | 311.3 |
| 2 | Miami (Florida) | 3 | 213 | 457 | 211 | 670 | 3.18 | 223.3 |
| 3 | Boston College | 4 | 364 | 579 | 244 | 943 | 3.86 | 235.8 |
| 3 | Florida State | 4 | 823 | 831 | 244 | 1654 | 6.78 | 413.5 |
| 5 | Virginia Tech | 4 | 454 | 603 | 253 | 1057 | 4.18 | 264.3 |
| 6 | Clemson | 4 | 371 | 503 | 256 | 874 | 3.41 | 218.5 |
| 7 | Georgia Tech | 4 | 484 | 873 | 265 | 1357 | 5.12 | 339.3 |
| 8 | Wake Forest | 4 | 354 | 1000 | 269 | 1354 | 5.03 | 338.5 |
| 9 | Duke | 4 | 516 | 925 | 276 | 1441 | 5.22 | 360.3 |
| 10 | Pittsburgh | 4 | 245 | 1444 | 277 | 1689 | 6.10 | 422.3 |
| 11 | Louisville | 4 | 488 | 625 | 287 | 1113 | 3.88 | 278.3 |
| 12 | Syracuse | 4 | 837 | 1030 | 292 | 1867 | 6.39 | 466.8 |
| 13 | Virginia | 4 | 704 | 1224 | 295 | 1928 | 6.54 | 482.0 |
| 14 | North Carolina | 4 | 961 | 738 | 302 | 1699 | 5.63 | 424.8 |