2016 Atlantic Coast Conference Leaders Total Defense - Games Lost Only through 01/09/2017
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | 156 | 308 | 71 | 464 | 6.54 | 464.0 |
| 2 | Florida State | 3 | 580 | 999 | 217 | 1579 | 7.28 | 526.3 |
| 3 | Georgia Tech | 4 | 750 | 1090 | 260 | 1840 | 7.08 | 460.0 |
| 4 | Louisville | 4 | 671 | 1173 | 283 | 1844 | 6.52 | 461.0 |
| 5 | Virginia Tech | 4 | 886 | 818 | 305 | 1704 | 5.59 | 426.0 |
| 6 | Miami (Florida) | 4 | 726 | 1074 | 310 | 1800 | 5.81 | 450.0 |
| 7 | North Carolina | 5 | 1093 | 887 | 382 | 1980 | 5.18 | 396.0 |
| 8 | Pittsburgh | 5 | 694 | 1969 | 397 | 2663 | 6.71 | 532.6 |
| 9 | Boston College | 6 | 1060 | 1625 | 405 | 2685 | 6.63 | 447.5 |
| 10 | Wake Forest | 6 | 1254 | 1212 | 424 | 2466 | 5.82 | 411.0 |
| 11 | North Carolina State | 6 | 788 | 1899 | 458 | 2687 | 5.87 | 447.8 |
| 12 | Duke | 8 | 1637 | 2076 | 549 | 3713 | 6.76 | 464.1 |
| 13 | Syracuse | 8 | 2127 | 2563 | 591 | 4690 | 7.94 | 586.3 |
| 14 | Virginia | 10 | 2081 | 2353 | 682 | 4434 | 6.50 | 443.4 |