2022 Atlantic Coast Conference Leaders Total Defense - Games Lost Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 3 | 442 | 696 | 200 | 1138 | 5.69 | 379.3 |
| 2 | Florida State | 3 | 520 | 562 | 221 | 1082 | 4.90 | 360.7 |
| 3 | Duke | 4 | 660 | 1126 | 274 | 1786 | 6.52 | 446.5 |
| 4 | Pittsburgh | 4 | 531 | 1005 | 280 | 1536 | 5.49 | 384.0 |
| 5 | Louisville | 5 | 947 | 1190 | 321 | 2137 | 6.66 | 427.4 |
| 6 | North Carolina State | 5 | 591 | 1168 | 337 | 1759 | 5.22 | 351.8 |
| 7 | North Carolina | 5 | 809 | 1269 | 341 | 2078 | 6.09 | 415.6 |
| 8 | Wake Forest | 5 | 766 | 1619 | 378 | 2385 | 6.31 | 477.0 |
| 9 | Syracuse | 6 | 1219 | 1108 | 447 | 2327 | 5.21 | 387.8 |
| 10 | Miami (Florida) | 7 | 1262 | 1720 | 463 | 2982 | 6.44 | 426.0 |
| 11 | Virginia | 7 | 1217 | 1503 | 508 | 2720 | 5.35 | 388.6 |
| 12 | Georgia Tech | 7 | 1602 | 1469 | 511 | 3071 | 6.01 | 438.7 |
| 13 | Virginia Tech | 8 | 1330 | 2067 | 588 | 3397 | 5.78 | 424.6 |
| 14 | Boston College | 9 | 1573 | 1905 | 591 | 3478 | 5.88 | 386.4 |