2025 American Conference Leaders Sacks - Games vs. FBS Power 5 Conference Teams Only through 10/31/2025
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | North Texas | 1 | 3.0 | 16 | 3.00 |
| 1 | Rice | 1 | 3.0 | 6 | 3.00 |
| 3 | Temple | 2 | 4.0 | 32 | 2.00 |
| 3 | Tulsa | 1 | 2.0 | 14 | 2.00 |
| 5 | Tulane | 3 | 4.0 | 31 | 1.33 |
| 6 | East Carolina | 2 | 2.0 | 6 | 1.00 |
| 6 | USF | 2 | 2.0 | 5 | 1.00 |
| 6 | Memphis | 1 | 1.0 | 9 | 1.00 |
| 6 | UAB | 1 | 1.0 | 5 | 1.00 |