2025 Big 12 Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 09/06/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Kansas State | 1 | 17 | 3 | 0 | 20 | 20.0 |
| 2 | Houston | 1 | 12 | 4 | 0 | 16 | 16.0 |
| 3 | UCF | 1 | 11 | 5 | 2 | 18 | 18.0 |
| 4 | Texas Tech | 1 | 4 | 6 | 0 | 10 | 10.0 |
| 5 | Kansas | 1 | 4 | 9 | 0 | 13 | 13.0 |
| 6 | West Virginia | 1 | 10 | 10 | 4 | 24 | 24.0 |
| 7 | Cincinnati | 1 | 6 | 11 | 4 | 21 | 21.0 |
| 8 | Colorado | 1 | 6 | 12 | 1 | 19 | 19.0 |
| 8 | Arizona | 1 | 7 | 12 | 2 | 21 | 21.0 |