2025 Conference USA Leaders Rushing Defense - Games in October Only through 11/01/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Jacksonville State | 3 | 77 | 268 | 3.48 | 5 | 25.67 | 89.33 |
| 2 | Missouri State | 3 | 85 | 283 | 3.33 | 1 | 28.33 | 94.33 |
| 3 | Middle Tennessee State | 3 | 120 | 290 | 2.42 | 2 | 40.00 | 96.67 |
| 4 | Liberty | 2 | 63 | 202 | 3.21 | 2 | 31.50 | 101.00 |
| 5 | New Mexico State | 3 | 88 | 309 | 3.51 | 2 | 29.33 | 103.00 |
| 6 | Delaware | 3 | 98 | 466 | 4.76 | 5 | 32.67 | 155.33 |
| 7 | UTEP | 3 | 129 | 469 | 3.64 | 3 | 43.00 | 156.33 |
| 8 | Western Kentucky | 3 | 110 | 479 | 4.35 | 5 | 36.67 | 159.67 |
| 9 | Kennesaw State | 3 | 120 | 493 | 4.11 | 3 | 40.00 | 164.33 |
| 10 | FIU | 4 | 134 | 686 | 5.12 | 8 | 33.50 | 171.50 |
| 11 | Louisiana Tech | 3 | 98 | 519 | 5.30 | 5 | 32.67 | 173.00 |
| 12 | Sam Houston State | 4 | 167 | 1065 | 6.38 | 14 | 41.75 | 266.25 |