2025 Conference USA Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 10/08/2025
| Name | Team | Yr | Pos | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Michael Richard | La Tech | JR | DB | 1 | 1 | 0 | 1 | 1.00 |
| 1 | Damonte Smith | MTSU | SR | NT | 1 | 1 | 0 | 1 | 1.00 |
| 1 | Xavier Smith | UTEP | JR | S | 1 | 1 | 0 | 1 | 1.00 |
| 1 | J.J. O'Neal | MO State | SR | S | 2 | 1 | 0 | 1 | 0.50 |