2022 American Athletic Conference Leaders Sacks - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | U.S. Naval Academy | 1 | 5.0 | 30 | 5.00 |
| 1 | East Carolina University | 1 | 5.0 | 28 | 5.00 |
| 3 | University of South Florida | 1 | 4.0 | 13 | 4.00 |
| 4 | Southern Methodist University | 2 | 6.0 | 45 | 3.00 |
| 5 | University of Houston | 1 | 2.0 | 18 | 2.00 |
| 5 | The University of Tulsa | 1 | 2.0 | 3 | 2.00 |
| 7 | University of Central Florida | 2 | 3.0 | 21 | 1.50 |
| 8 | University of Memphis | 2 | 2.0 | 13 | 1.00 |
| 8 | University of Cincinnati | 1 | 1.0 | 5 | 1.00 |