2022 American Athletic Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Cincinnati | 9 | 1271 | 1623 | 622 | 2894 | 4.65 | 321.6 |
| 2 | Tulane | 11 | 1754 | 2252 | 806 | 4006 | 4.97 | 364.2 |
| 3 | Memphis | 11 | 1390 | 2663 | 766 | 4053 | 5.29 | 368.5 |
| 4 | UCF | 10 | 1646 | 2368 | 680 | 4014 | 5.90 | 401.4 |
| 5 | Temple | 9 | 1970 | 1913 | 653 | 3883 | 5.95 | 431.4 |
| 6 | Tulsa | 10 | 1979 | 2235 | 704 | 4214 | 5.99 | 421.4 |
| 7 | Navy | 11 | 1054 | 2813 | 642 | 3867 | 6.02 | 351.5 |
| 8 | Houston | 11 | 1461 | 3114 | 759 | 4575 | 6.03 | 415.9 |
| 9 | SMU | 10 | 2127 | 2303 | 732 | 4430 | 6.05 | 443.0 |
| 10 | East Carolina | 11 | 1226 | 3295 | 726 | 4521 | 6.23 | 411.0 |
| 11 | South Florida | 9 | 2149 | 2763 | 634 | 4912 | 7.75 | 545.8 |