2022 American Athletic Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 1 | 84 | 189 | 54 | 273 | 5.06 | 273.0 |
| 2 | Cincinnati | 1 | 221 | 162 | 70 | 383 | 5.47 | 383.0 |
| 3 | Memphis | 2 | 283 | 608 | 153 | 891 | 5.82 | 445.5 |
| 4 | East Carolina | 1 | 41 | 350 | 67 | 391 | 5.84 | 391.0 |
| 5 | Tulane | 2 | 318 | 612 | 157 | 930 | 5.92 | 465.0 |
| 6 | Navy | 1 | 66 | 269 | 55 | 335 | 6.09 | 335.0 |
| 7 | South Florida | 1 | 235 | 329 | 87 | 564 | 6.48 | 564.0 |
| 8 | Tulsa | 1 | 357 | 125 | 72 | 482 | 6.69 | 482.0 |
| 9 | SMU | 2 | 501 | 437 | 121 | 938 | 7.75 | 469.0 |
| 10 | UCF | 2 | 409 | 630 | 130 | 1039 | 7.99 | 519.5 |