2022 American Athletic Conference Leaders Total Defense - Games in November Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 3 | 205 | 798 | 167 | 1003 | 6.01 | 334.3 |
| 2 | Memphis | 4 | 448 | 734 | 255 | 1182 | 4.64 | 295.5 |
| 3 | Cincinnati | 4 | 606 | 693 | 263 | 1299 | 4.94 | 324.8 |
| 4 | East Carolina | 3 | 194 | 1206 | 203 | 1400 | 6.90 | 466.7 |
| 5 | UCF | 4 | 850 | 660 | 268 | 1510 | 5.63 | 377.5 |
| 6 | Tulane | 4 | 823 | 709 | 308 | 1532 | 4.97 | 383.0 |
| 7 | Tulsa | 4 | 815 | 1013 | 281 | 1828 | 6.51 | 457.0 |
| 8 | Temple | 4 | 828 | 1050 | 283 | 1878 | 6.64 | 469.5 |
| 9 | Houston | 4 | 543 | 1378 | 300 | 1921 | 6.40 | 480.3 |
| 10 | SMU | 4 | 823 | 1158 | 281 | 1981 | 7.05 | 495.3 |
| 11 | South Florida | 4 | 1166 | 1128 | 283 | 2294 | 8.11 | 573.5 |