2022 American Athletic Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | East Carolina | 1 | 133 | 211 | 65 | 344 | 5.29 | 344.0 |
| 2 | Tulsa | 1 | 308 | 154 | 75 | 462 | 6.16 | 462.0 |
| 3 | Memphis | 1 | 97 | 450 | 83 | 547 | 6.59 | 547.0 |
| 4 | Temple | 2 | 314 | 387 | 123 | 701 | 5.70 | 350.5 |
| 5 | South Florida | 2 | 500 | 371 | 124 | 871 | 7.02 | 435.5 |
| 6 | Houston | 2 | 398 | 508 | 169 | 906 | 5.36 | 453.0 |
| 7 | SMU | 2 | 416 | 510 | 126 | 926 | 7.35 | 463.0 |
| 8 | Tulane | 2 | 318 | 612 | 157 | 930 | 5.92 | 465.0 |
| 9 | Cincinnati | 3 | 579 | 635 | 247 | 1214 | 4.91 | 404.7 |
| 10 | UCF | 3 | 531 | 688 | 206 | 1219 | 5.92 | 406.3 |