2022 American Athletic Conference Leaders Total Defense - Games in October Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 3 | 511 | 682 | 203 | 1193 | 5.88 | 397.7 |
| 2 | Tulane | 3 | 352 | 859 | 200 | 1211 | 6.06 | 403.7 |
| 3 | Cincinnati | 4 | 598 | 814 | 302 | 1412 | 4.68 | 353.0 |
| 4 | UCF | 4 | 354 | 1206 | 289 | 1560 | 5.40 | 390.0 |
| 5 | Memphis | 4 | 504 | 1073 | 287 | 1577 | 5.49 | 394.3 |
| 6 | Tulsa | 4 | 895 | 707 | 288 | 1602 | 5.56 | 400.5 |
| 7 | Temple | 4 | 963 | 783 | 298 | 1746 | 5.86 | 436.5 |
| 8 | SMU | 4 | 893 | 878 | 316 | 1771 | 5.60 | 442.8 |
| 9 | Navy | 5 | 530 | 1305 | 286 | 1835 | 6.42 | 367.0 |
| 10 | South Florida | 4 | 669 | 1374 | 282 | 2043 | 7.24 | 510.8 |
| 11 | East Carolina | 5 | 701 | 1450 | 339 | 2151 | 6.35 | 430.2 |