2022 American Athletic Conference Leaders Total Defense - Games Lost Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulane | 2 | 395 | 326 | 136 | 721 | 5.30 | 360.5 |
| 2 | Cincinnati | 4 | 990 | 764 | 297 | 1754 | 5.91 | 438.5 |
| 3 | East Carolina | 5 | 511 | 1392 | 334 | 1903 | 5.70 | 380.6 |
| 4 | UCF | 5 | 1052 | 1079 | 340 | 2131 | 6.27 | 426.2 |
| 5 | Houston | 5 | 860 | 1392 | 381 | 2252 | 5.91 | 450.4 |
| 6 | SMU | 6 | 1274 | 1222 | 384 | 2496 | 6.50 | 416.0 |
| 7 | Memphis | 6 | 866 | 1812 | 457 | 2678 | 5.86 | 446.3 |
| 8 | Navy | 8 | 835 | 1953 | 465 | 2788 | 6.00 | 348.5 |
| 9 | Tulsa | 7 | 1698 | 1308 | 501 | 3006 | 6.00 | 429.4 |
| 10 | Temple | 9 | 1824 | 2030 | 634 | 3854 | 6.08 | 428.2 |
| 11 | South Florida | 11 | 2649 | 3134 | 758 | 5783 | 7.63 | 525.7 |