2022 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 10 | 52 | 106 | 22 | 180 | 18.0 |
| 2 | Clemson | 11 | 64 | 115 | 21 | 200 | 18.2 |
| 3 | Pittsburgh | 11 | 66 | 109 | 26 | 201 | 18.3 |
| 4 | Virginia | 8 | 71 | 81 | 17 | 169 | 21.1 |
| 5 | North Carolina | 10 | 73 | 122 | 13 | 208 | 20.8 |
| 5 | Virginia Tech | 8 | 73 | 83 | 20 | 176 | 22.0 |
| 7 | Duke | 10 | 74 | 130 | 15 | 219 | 21.9 |
| 8 | Wake Forest | 10 | 76 | 126 | 11 | 213 | 21.3 |
| 9 | Boston College | 9 | 77 | 87 | 23 | 187 | 20.8 |
| 10 | Miami (Florida) | 9 | 83 | 81 | 20 | 184 | 20.4 |
| 11 | Louisville | 9 | 85 | 86 | 19 | 190 | 21.1 |
| 12 | Syracuse | 10 | 97 | 103 | 15 | 215 | 21.5 |
| 13 | Florida State | 11 | 103 | 95 | 21 | 219 | 19.9 |
| 13 | Georgia Tech | 10 | 103 | 96 | 22 | 221 | 22.1 |