2022 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS non-Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Pittsburgh | 1 | 4 | 5 | 1 | 10 | 10.0 |
| 2 | Virginia | 1 | 5 | 13 | 2 | 20 | 20.0 |
| 3 | Miami (Florida) | 2 | 8 | 17 | 1 | 26 | 13.0 |
| 4 | North Carolina State | 2 | 10 | 14 | 2 | 26 | 13.0 |
| 4 | Florida State | 1 | 10 | 7 | 1 | 18 | 18.0 |
| 6 | Virginia Tech | 2 | 12 | 16 | 6 | 34 | 17.0 |
| 7 | Duke | 2 | 16 | 16 | 1 | 33 | 16.5 |
| 7 | Georgia Tech | 1 | 16 | 3 | 5 | 24 | 24.0 |
| 9 | Boston College | 2 | 18 | 15 | 2 | 35 | 17.5 |
| 10 | Clemson | 2 | 19 | 16 | 3 | 38 | 19.0 |
| 11 | Syracuse | 2 | 21 | 10 | 1 | 32 | 16.0 |
| 12 | Wake Forest | 2 | 22 | 17 | 2 | 41 | 20.5 |
| 13 | Louisville | 4 | 26 | 19 | 4 | 49 | 12.3 |
| 14 | North Carolina | 3 | 46 | 33 | 15 | 94 | 31.3 |