2021 Atlantic Coast Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 9 | 51 | 82 | 27 | 160 | 17.8 |
| 2 | Pittsburgh | 11 | 69 | 134 | 29 | 232 | 21.1 |
| 3 | Clemson | 11 | 70 | 118 | 20 | 208 | 18.9 |
| 4 | Syracuse | 9 | 74 | 83 | 13 | 170 | 18.9 |
| 5 | Florida State | 9 | 80 | 94 | 20 | 194 | 21.6 |
| 6 | Miami (Florida) | 10 | 85 | 110 | 22 | 217 | 21.7 |
| 7 | Boston College | 9 | 87 | 75 | 16 | 178 | 19.8 |
| 8 | Virginia | 9 | 88 | 99 | 25 | 212 | 23.6 |
| 9 | Louisville | 10 | 90 | 124 | 20 | 234 | 23.4 |
| 10 | Georgia Tech | 9 | 91 | 109 | 17 | 217 | 24.1 |
| 11 | Virginia Tech | 10 | 94 | 98 | 17 | 209 | 20.9 |
| 12 | North Carolina | 10 | 97 | 113 | 28 | 238 | 23.8 |
| 13 | Duke | 10 | 101 | 134 | 19 | 254 | 25.4 |
| 14 | Wake Forest | 11 | 112 | 114 | 20 | 246 | 22.4 |