2022 Atlantic Coast Conference Leaders Opponent First Downs - Games in November Only through 01/09/2023
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 16 | 52 | 10 | 78 | 19.5 |
| 2 | Pittsburgh | 4 | 19 | 32 | 10 | 61 | 15.3 |
| 3 | Virginia | 2 | 23 | 24 | 3 | 50 | 25.0 |
| 4 | Clemson | 4 | 25 | 31 | 3 | 59 | 14.8 |
| 5 | Duke | 4 | 27 | 47 | 2 | 76 | 19.0 |
| 6 | Virginia Tech | 3 | 28 | 28 | 6 | 62 | 20.7 |
| 7 | North Carolina | 4 | 29 | 49 | 6 | 84 | 21.0 |
| 8 | Wake Forest | 4 | 34 | 60 | 7 | 101 | 25.3 |
| 9 | Florida State | 4 | 35 | 19 | 8 | 62 | 15.5 |
| 10 | Louisville | 4 | 36 | 29 | 7 | 72 | 18.0 |
| 11 | Georgia Tech | 4 | 41 | 28 | 5 | 74 | 18.5 |
| 12 | Boston College | 4 | 42 | 36 | 8 | 86 | 21.5 |
| 13 | Miami (Florida) | 4 | 44 | 43 | 12 | 99 | 24.8 |
| 14 | Syracuse | 4 | 47 | 49 | 5 | 101 | 25.3 |