2021 Louisville Cardinals Total Offense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 2768 | 3061 | 873 | 5829 | 6.68 | 448.4 |
| at Home | 7 | 1443 | 1572 | 449 | 3015 | 6.71 | 430.7 |
| on Road/Neutral Site | 6 | 1325 | 1489 | 424 | 2814 | 6.64 | 469.0 |
| in Wins | 6 | 1358 | 1487 | 401 | 2845 | 7.09 | 474.2 |
| in Losses | 7 | 1410 | 1574 | 472 | 2984 | 6.32 | 426.3 |
| vs. Conference | 8 | 1888 | 1865 | 533 | 3753 | 7.04 | 469.1 |
| vs. Non-Conference | 5 | 880 | 1196 | 340 | 2076 | 6.11 | 415.2 |
| vs. Ranked (AP) | 5 | 945 | 1110 | 346 | 2055 | 5.94 | 411.0 |
| vs. Unranked (AP) | 8 | 1823 | 1951 | 527 | 3774 | 7.16 | 471.8 |
| vs. FBS (I-A) | 12 | 2610 | 2777 | 809 | 5387 | 6.66 | 448.9 |
| vs. FCS (I-AA) | 1 | 158 | 284 | 64 | 442 | 6.91 | 442.0 |
| vs. FBS Winning | 7 | 1368 | 1614 | 486 | 2982 | 6.14 | 426.0 |
| vs. FBS Non-Winning | 5 | 1242 | 1163 | 323 | 2405 | 7.45 | 481.0 |
| vs. FBS Power 5 | 10 | 2187 | 2273 | 669 | 4460 | 6.67 | 446.0 |
| vs. FBS non-Power 5 | 2 | 423 | 504 | 140 | 927 | 6.62 | 463.5 |
| in August/September | 4 | 635 | 1058 | 298 | 1693 | 5.68 | 423.3 |
| in October | 4 | 987 | 905 | 266 | 1892 | 7.11 | 473.0 |
| in November | 4 | 914 | 904 | 245 | 1818 | 7.42 | 454.5 |
| in December/January | 1 | 232 | 194 | 64 | 426 | 6.66 | 426.0 |