2021 Louisville Cardinals First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 121 | 133 | 21 | 275 |
| at Home | 7 | 60 | 68 | 10 | 138 |
| on Road/Neutral Site | 6 | 61 | 65 | 11 | 137 |
| in Wins | 6 | 57 | 67 | 7 | 131 |
| in Losses | 7 | 64 | 66 | 14 | 144 |
| vs. Conference | 8 | 78 | 76 | 14 | 168 |
| vs. Non-Conference | 5 | 43 | 57 | 7 | 107 |
| vs. Ranked (AP) | 5 | 45 | 45 | 11 | 101 |
| vs. Unranked (AP) | 8 | 76 | 88 | 10 | 174 |
| vs. FBS (I-A) | 12 | 113 | 123 | 21 | 257 |
| vs. FCS (I-AA) | 1 | 8 | 10 | 0 | 18 |
| vs. FBS Winning | 7 | 65 | 70 | 13 | 148 |
| vs. FBS Non-Winning | 5 | 48 | 53 | 8 | 109 |
| vs. FBS Power 5 | 10 | 93 | 98 | 19 | 210 |
| vs. FBS non-Power 5 | 2 | 20 | 25 | 2 | 47 |
| in August/September | 4 | 29 | 51 | 5 | 85 |
| in October | 4 | 40 | 35 | 9 | 84 |
| in November | 4 | 39 | 38 | 6 | 83 |
| in December/January | 1 | 13 | 9 | 1 | 23 |