2022 Louisville Cardinals Total Defense Split Stats through 01/09/2023
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 13 | 1742 | 2561 | 848 | 4303 | 5.07 | 331.0 |
| at Home | 6 | 715 | 1110 | 407 | 1825 | 4.48 | 304.2 |
| on Road/Neutral Site | 7 | 1027 | 1451 | 441 | 2478 | 5.62 | 354.0 |
| in Wins | 8 | 795 | 1371 | 527 | 2166 | 4.11 | 270.8 |
| in Losses | 5 | 947 | 1190 | 321 | 2137 | 6.66 | 427.4 |
| vs. Conference | 8 | 1132 | 1997 | 548 | 3129 | 5.71 | 391.1 |
| vs. Non-Conference | 5 | 610 | 564 | 300 | 1174 | 3.91 | 234.8 |
| vs. Ranked (AP) | 3 | 605 | 615 | 203 | 1220 | 6.01 | 406.7 |
| vs. Unranked (AP) | 10 | 1137 | 1946 | 645 | 3083 | 4.78 | 308.3 |
| vs. FBS (I-A) | 13 | 1742 | 2561 | 848 | 4303 | 5.07 | 331.0 |
| vs. FCS (I-AA) | 0 | 0 | 0 | 0 | 0 | - | - |
| vs. FBS Winning | 10 | 1544 | 1834 | 669 | 3378 | 5.05 | 337.8 |
| vs. FBS Non-Winning | 3 | 198 | 727 | 179 | 925 | 5.17 | 308.3 |
| vs. FBS Power 5 | 9 | 1290 | 2185 | 609 | 3475 | 5.71 | 386.1 |
| vs. FBS non-Power 5 | 4 | 452 | 376 | 239 | 828 | 3.46 | 207.0 |
| in August/September | 4 | 653 | 748 | 265 | 1401 | 5.29 | 350.3 |
| in October | 4 | 410 | 1085 | 272 | 1495 | 5.50 | 373.8 |
| in November | 4 | 624 | 645 | 258 | 1269 | 4.92 | 317.3 |
| in December/January | 1 | 55 | 83 | 53 | 138 | 2.60 | 138.0 |