2021 Big Ten Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wisconsin | 3 | 198 | 402 | 163 | 600 | 3.68 | 200.0 |
| 2 | Iowa | 2 | 175 | 340 | 142 | 515 | 3.63 | 257.5 |
| 3 | Rutgers | 1 | 113 | 148 | 63 | 261 | 4.14 | 261.0 |
| 4 | Michigan | 2 | 287 | 237 | 122 | 524 | 4.30 | 262.0 |
| 5 | Minnesota | 2 | 126 | 407 | 122 | 533 | 4.37 | 266.5 |
| 6 | Purdue | 2 | 235 | 322 | 125 | 557 | 4.46 | 278.5 |
| 7 | Penn State | 1 | 69 | 226 | 71 | 295 | 4.15 | 295.0 |
| 8 | Northwestern | 1 | 179 | 169 | 63 | 348 | 5.52 | 348.0 |
| 9 | Nebraska | 1 | 135 | 224 | 83 | 359 | 4.33 | 359.0 |
| 10 | Ohio State | 2 | 149 | 581 | 156 | 730 | 4.68 | 365.0 |
| 11 | Illinois | 2 | 298 | 471 | 131 | 769 | 5.87 | 384.5 |
| 12 | Indiana | 2 | 211 | 575 | 136 | 786 | 5.78 | 393.0 |
| 13 | Maryland | 1 | 150 | 308 | 80 | 458 | 5.73 | 458.0 |
| 14 | Michigan State | 1 | 72 | 488 | 91 | 560 | 6.15 | 560.0 |