2021 American Athletic Conference Leaders Fumbles Lost - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Fumbles | Fumbles Lost | Fumble Lost % | |
|---|---|---|---|---|---|
| 1 | University of Houston | 13 | 11 | 2 | 18.18 |
| 2 | U.S. Naval Academy | 9 | 15 | 4 | 26.67 |
| 3 | Tulane University | 8 | 8 | 5 | 62.50 |
| 3 | Southern Methodist University | 10 | 10 | 5 | 50.00 |
| 3 | University of Central Florida | 12 | 12 | 5 | 41.67 |
| 6 | The University of Tulsa | 9 | 10 | 6 | 60.00 |
| 6 | University of South Florida | 8 | 13 | 6 | 46.15 |
| 8 | East Carolina University | 10 | 14 | 7 | 50.00 |
| 9 | University of Memphis | 11 | 13 | 8 | 61.54 |
| 10 | University of Cincinnati | 11 | 13 | 9 | 69.23 |
| 11 | Temple University | 10 | 14 | 10 | 71.43 |