2021 American Athletic Conference Leaders Sacks - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | University of Houston | 5 | 18.0 | 118 | 3.60 |
| 2 | Tulane University | 4 | 11.0 | 90 | 2.75 |
| 3 | East Carolina University | 4 | 10.0 | 67 | 2.50 |
| 4 | The University of Tulsa | 5 | 12.0 | 66 | 2.40 |
| 5 | Southern Methodist University | 4 | 7.0 | 39 | 1.75 |
| 6 | University of Central Florida | 5 | 8.0 | 45 | 1.60 |
| 6 | University of Cincinnati | 5 | 8.0 | 43 | 1.60 |
| 8 | University of Memphis | 4 | 6.0 | 51 | 1.50 |
| 8 | Temple University | 4 | 6.0 | 46 | 1.50 |
| 10 | U.S. Naval Academy | 4 | 5.0 | 33 | 1.25 |
| 11 | University of South Florida | 4 | 3.0 | 17 | 0.75 |