2021 American Athletic Conference Leaders Sacks - Games in November Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | University of Central Florida | 4 | 17.0 | 126 | 4.25 |
| 2 | University of Memphis | 4 | 16.0 | 98 | 4.00 |
| 3 | Tulane University | 4 | 15.0 | 74 | 3.75 |
| 4 | Southern Methodist University | 4 | 11.0 | 69 | 2.75 |
| 4 | University of Cincinnati | 4 | 11.0 | 62 | 2.75 |
| 6 | University of Houston | 4 | 10.0 | 51 | 2.50 |
| 7 | The University of Tulsa | 4 | 8.0 | 36 | 2.00 |
| 7 | U.S. Naval Academy | 3 | 6.0 | 55 | 2.00 |
| 9 | East Carolina University | 4 | 7.0 | 31 | 1.75 |
| 10 | Temple University | 4 | 4.0 | 29 | 1.00 |
| 10 | University of South Florida | 4 | 4.0 | 26 | 1.00 |