2022 American Athletic Conference Leaders Sacks - Games vs. Non-Conference Teams Only through 01/09/2023
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Temple University | 4 | 15.0 | 90 | 3.75 |
| 2 | U.S. Naval Academy | 4 | 14.0 | 70 | 3.50 |
| 3 | University of Cincinnati | 5 | 13.0 | 95 | 2.60 |
| 3 | University of Houston | 5 | 13.0 | 77 | 2.60 |
| 5 | Southern Methodist University | 5 | 12.0 | 83 | 2.40 |
| 6 | East Carolina University | 5 | 11.0 | 91 | 2.20 |
| 7 | University of Central Florida | 5 | 10.0 | 58 | 2.00 |
| 8 | University of Memphis | 5 | 9.0 | 58 | 1.80 |
| 9 | University of South Florida | 4 | 6.0 | 27 | 1.50 |
| 10 | The University of Tulsa | 4 | 4.0 | 18 | 1.00 |
| 11 | Tulane University | 5 | 4.0 | 24 | 0.80 |