2021 American Athletic Conference Leaders Sacks - Games Won Only through 01/10/2022
| Name | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|
| 1 | Tulane University | 2 | 10.0 | 77 | 5.00 |
| 2 | University of Central Florida | 9 | 32.0 | 208 | 3.56 |
| 3 | University of Houston | 12 | 39.0 | 244 | 3.25 |
| 4 | University of Cincinnati | 13 | 37.0 | 223 | 2.85 |
| 5 | The University of Tulsa | 7 | 19.0 | 96 | 2.71 |
| 6 | University of Memphis | 6 | 16.0 | 125 | 2.67 |
| 6 | Temple University | 3 | 8.0 | 54 | 2.67 |
| 8 | Southern Methodist University | 8 | 20.0 | 126 | 2.50 |
| 9 | U.S. Naval Academy | 4 | 8.0 | 57 | 2.00 |
| 10 | East Carolina University | 7 | 12.0 | 68 | 1.71 |
| 11 | University of South Florida | 2 | 2.0 | 9 | 1.00 |