2021 American Athletic Conference Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 9 | 1022 | 1770 | 542 | 2792 | 5.15 | 310.2 |
| 2 | Navy | 6 | 814 | 1123 | 321 | 1937 | 6.03 | 322.8 |
| 3 | Cincinnati | 7 | 1071 | 1344 | 518 | 2415 | 4.66 | 345.0 |
| 4 | Tulsa | 7 | 996 | 1439 | 442 | 2435 | 5.51 | 347.9 |
| 5 | East Carolina | 6 | 1145 | 1325 | 371 | 2470 | 6.66 | 411.7 |
| 6 | SMU | 6 | 846 | 1830 | 425 | 2676 | 6.30 | 446.0 |
| 7 | UCF | 6 | 1451 | 1236 | 451 | 2687 | 5.96 | 447.8 |
| 8 | South Florida | 6 | 1212 | 1481 | 397 | 2693 | 6.78 | 448.8 |
| 9 | Temple | 6 | 1553 | 1205 | 454 | 2758 | 6.07 | 459.7 |
| 10 | Memphis | 5 | 902 | 1430 | 380 | 2332 | 6.14 | 466.4 |
| 11 | Tulane | 6 | 1076 | 1954 | 462 | 3030 | 6.56 | 505.0 |