2021 American Athletic Conference Leaders Total Defense - Games at Home Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 5 | 493 | 946 | 316 | 1439 | 4.55 | 287.8 |
| 2 | Cincinnati | 7 | 1017 | 1025 | 478 | 2042 | 4.27 | 291.7 |
| 3 | UCF | 7 | 619 | 1495 | 495 | 2114 | 4.27 | 302.0 |
| 4 | Temple | 6 | 1093 | 930 | 406 | 2023 | 4.98 | 337.2 |
| 5 | Tulane | 6 | 825 | 1301 | 426 | 2126 | 4.99 | 354.3 |
| 6 | East Carolina | 6 | 795 | 1457 | 419 | 2252 | 5.37 | 375.3 |
| 7 | Navy | 6 | 758 | 1495 | 375 | 2253 | 6.01 | 375.5 |
| 8 | Memphis | 7 | 1103 | 1581 | 545 | 2684 | 4.92 | 383.4 |
| 9 | SMU | 6 | 805 | 1507 | 417 | 2312 | 5.54 | 385.3 |
| 10 | Tulsa | 6 | 861 | 1518 | 443 | 2379 | 5.37 | 396.5 |
| 11 | South Florida | 6 | 1275 | 1679 | 412 | 2954 | 7.17 | 492.3 |