2021 American Athletic Conference Leaders Rushing Defense - When Losing By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Memphis | 2 | 15 | 41 | 2.73 | 0 | 10 | 2 | 1 | 0 |
| 2 | Houston | 1 | 14 | 94 | 6.71 | 1 | 42 | 3 | 4 | 1 |
| 3 | Cincinnati | 1 | 12 | 84 | 7.00 | 0 | 19 | 5 | 3 | 0 |
| 3 | Tulsa | 3 | 32 | 114 | 3.56 | 1 | 22 | 5 | 3 | 2 |
| 5 | East Carolina | 3 | 34 | 210 | 6.18 | 2 | 46 | 7 | 6 | 3 |
| 6 | Navy | 5 | 44 | 153 | 3.48 | 4 | 23 | 8 | 3 | 1 |
| 7 | SMU | 1 | 32 | 190 | 5.94 | 0 | 33 | 9 | 4 | 1 |
| 8 | UCF | 3 | 51 | 345 | 6.76 | 5 | 79 | 15 | 11 | 5 |
| 9 | Tulane | 5 | 93 | 430 | 4.62 | 6 | 30 | 23 | 16 | 5 |
| 10 | South Florida | 7 | 118 | 760 | 6.44 | 6 | 80 | 35 | 23 | 8 |
| 11 | Temple | 9 | 184 | 942 | 5.12 | 15 | 58 | 42 | 26 | 11 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||