2021 American Athletic Conference Leaders Interceptions - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Marcus Jones | Houston | SR | CB | 9 | 5 | 2 | 0 | 0.56 |
| 2 | Macon Clark | Tulane | JR | S | 8 | 3 | 78 | 0 | 0.38 |
| 2 | Warren Saba | ECU | SR | SAF | 8 | 3 | 31 | 0 | 0.38 |
| 2 | TieNeal Martin | Tulsa | SR | S | 8 | 3 | 0 | 0 | 0.38 |
| 2 | Coby Bryant | Cincinnati | SR | CB | 9 | 3 | 95 | 1 | 0.33 |
| 6 | Jalen Ware | Temple | JR | SAF | 6 | 2 | 20 | 0 | 0.33 |
| 6 | Christian Williams | S Florida | SO | S | 7 | 2 | 61 | 0 | 0.29 |
| 6 | Antonio Grier | S Florida | SR | LB | 8 | 2 | 69 | 1 | 0.25 |
| 6 | Travon Fuller | Tulsa | SR | CB | 8 | 2 | 60 | 0 | 0.25 |
| 6 | Gleson Sprewell | Houston | SR | S | 8 | 2 | 44 | 0 | 0.25 |
| 6 | Rodney Owens | Memphis | SR | DB | 8 | 2 | 25 | 0 | 0.25 |
| 6 | Dwayne Boyles | S Florida | SR | LB | 8 | 2 | 4 | 0 | 0.25 |
| 6 | Jacobi Francis | Memphis | SR | DB | 8 | 2 | 1 | 0 | 0.25 |
| 6 | Ja'Quan McMillian | ECU | SO | CB | 8 | 2 | -1 | 0 | 0.25 |
| 6 | Gervarrius Owens | Houston | JR | S | 9 | 2 | 73 | 1 | 0.22 |
| 6 | Deshawn Pace | Cincinnati | SO | LB | 9 | 2 | 12 | 0 | 0.22 |
| 17 | Juan Powell | ECU | FR | SAF | 5 | 1 | 4 | 0 | 0.20 |
| 17 | Johnny Hodges | Navy | JR | LB | 6 | 1 | 0 | 0 | 0.17 |
| 17 | Dyllon Lester | UCF | JR | DB | 7 | 1 | 34 | 0 | 0.14 |
| 17 | Tatum Bethune | UCF | JR | LB | 7 | 1 | 23 | 0 | 0.14 |
| 17 | Jeremiah Jean-Baptiste | UCF | JR | LB | 7 | 1 | 8 | 0 | 0.14 |
| 17 | Teagan Wilk | ECU | FR | SAF | 7 | 1 | 6 | 0 | 0.14 |
| 17 | Jamal Glenn | Navy | SR | CB | 7 | 1 | 1 | 0 | 0.14 |
| 17 | Shawn Dourseau | ECU | SO | SAF | 8 | 1 | 33 | 0 | 0.13 |
| 17 | Malik Fleming | ECU | SO | CB | 8 | 1 | 31 | 1 | 0.13 |
| 17 | Divaad Wilson | UCF | JR | DB | 8 | 1 | 25 | 0 | 0.13 |
| 17 | Freddie Johnson | Temple | SR | CB | 8 | 1 | 25 | 0 | 0.13 |
| 17 | Davonte Brown | UCF | SO | DB | 8 | 1 | 14 | 0 | 0.13 |
| 17 | Quindell Johnson | Memphis | JR | DB | 8 | 1 | 14 | 0 | 0.13 |
| 17 | Trevor Denbow | SMU | SR | S | 8 | 1 | 11 | 0 | 0.13 |
| 17 | Delano Robinson | SMU | SR | LB | 8 | 1 | 8 | 0 | 0.13 |
| 17 | Kevin Henry | Tulane | SR | LB | 8 | 1 | 4 | 0 | 0.13 |
| 17 | Arquon Bush | Cincinnati | JR | CB | 8 | 1 | 1 | 0 | 0.13 |
| 17 | Jireh Wilson | ECU | SO | SAF | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Tyrez Lindsey | Memphis | SR | DB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | JJ Russell | Memphis | SR | LB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Xavier Cullens | Memphis | SR | LB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Mekhi LaPointe | S Florida | SR | DB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Jimmy Phillips Jr. | SMU | SR | LB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Jadon Canady | Tulane | FR | DB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Jaise Oliver | Tulsa | SO | S | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Bryson Powers | Tulsa | SR | S | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Diego Fagot | Navy | SR | LB | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Taylor Robinson | Navy | JR | BAN | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Rayuan Lane | Navy | FR | S | 8 | 1 | 0 | 0 | 0.13 |
| 17 | Isaac Slade-Matautia | SMU | JR | LB | 8 | 1 | -8 | 0 | 0.13 |
| 17 | Joel Dublanko | Cincinnati | SR | LB | 9 | 1 | 9 | 0 | 0.11 |
| 17 | Ja'von Hicks | Cincinnati | SR | S | 9 | 1 | 7 | 0 | 0.11 |
| 17 | Ahmad Gardner | Cincinnati | JR | CB | 9 | 1 | 3 | 0 | 0.11 |
| 17 | Darrian Beavers | Cincinnati | SR | LB | 9 | 1 | 0 | 0 | 0.11 |