2021 American Athletic Conference Leaders Interceptions - Games Lost Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Warren Saba | ECU | SR | SAF | 5 | 3 | 0 | 0 | 0.60 |
| 1 | Macon Clark | Tulane | JR | S | 10 | 3 | 45 | 0 | 0.30 |
| 3 | Jacobi Francis | Memphis | SR | DB | 6 | 2 | 1 | 0 | 0.33 |
| 3 | Christian Williams | S Florida | SO | S | 7 | 2 | 61 | 0 | 0.29 |
| 3 | Jalen Ware | Temple | JR | SAF | 7 | 2 | 20 | 0 | 0.29 |
| 3 | Dwayne Boyles | S Florida | SR | LB | 10 | 2 | 4 | 0 | 0.20 |
| 3 | Jadon Canady | Tulane | FR | DB | 10 | 2 | 0 | 0 | 0.20 |
| 8 | Bryan Cook | Cincinnati | SR | S | 1 | 1 | 0 | 0 | 1.00 |
| 8 | Tatum Bethune | UCF | JR | LB | 3 | 1 | 23 | 0 | 0.33 |
| 8 | Kevin Brennan | Navy | SR | FS | 4 | 1 | 15 | 0 | 0.25 |
| 8 | Trevor Denbow | SMU | SR | S | 4 | 1 | 11 | 0 | 0.25 |
| 8 | Delano Robinson | SMU | SR | LB | 4 | 1 | 8 | 0 | 0.25 |
| 8 | Tre'mon Morris-Brash | UCF | JR | DL | 4 | 1 | 0 | 0 | 0.25 |
| 8 | Jimmy Phillips Jr. | SMU | SR | LB | 4 | 1 | 0 | 0 | 0.25 |
| 8 | Justin Wright | Tulsa | JR | LB | 5 | 1 | 55 | 1 | 0.20 |
| 8 | Ja'Quan McMillian | ECU | SO | CB | 5 | 1 | 20 | 0 | 0.20 |
| 8 | Juan Powell | ECU | FR | SAF | 5 | 1 | 4 | 0 | 0.20 |
| 8 | Jaise Oliver | Tulsa | SO | S | 5 | 1 | 0 | 0 | 0.20 |
| 8 | TieNeal Martin | Tulsa | SR | S | 5 | 1 | 0 | 0 | 0.20 |
| 8 | Rodney Owens | Memphis | SR | DB | 6 | 1 | 25 | 0 | 0.17 |
| 8 | Lance Robinson | Tulane | SO | DB | 6 | 1 | 13 | 0 | 0.17 |
| 8 | Tyrez Lindsey | Memphis | SR | DB | 6 | 1 | 0 | 0 | 0.17 |
| 8 | JJ Russell | Memphis | SR | LB | 6 | 1 | 0 | 0 | 0.17 |
| 8 | Travon Fuller | Tulsa | SR | CB | 6 | 1 | 0 | 0 | 0.17 |
| 8 | Mbiti Williams Jr. | Navy | FR | CB | 7 | 1 | 7 | 0 | 0.14 |
| 8 | Jamal Glenn | Navy | SR | CB | 7 | 1 | 1 | 0 | 0.14 |
| 8 | Johnny Hodges | Navy | JR | LB | 7 | 1 | 0 | 0 | 0.14 |
| 8 | Brock Nichols | S Florida | SR | S | 8 | 1 | 38 | 0 | 0.13 |
| 8 | Matthew Hill | S Florida | SO | S | 8 | 1 | 27 | 0 | 0.13 |
| 8 | Keyshawn Paul | Temple | JR | CB | 8 | 1 | 0 | 0 | 0.13 |
| 8 | Diego Fagot | Navy | SR | LB | 8 | 1 | 0 | 0 | 0.13 |
| 8 | Freddie Johnson | Temple | SR | CB | 9 | 1 | 25 | 0 | 0.11 |
| 8 | Antonio Grier | S Florida | SR | LB | 10 | 1 | 69 | 1 | 0.10 |
| 8 | Mekhi LaPointe | S Florida | SR | DB | 10 | 1 | 50 | 0 | 0.10 |
| 8 | Kevin Henry | Tulane | SR | LB | 10 | 1 | 4 | 0 | 0.10 |