2021 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 1 | -21 | 120 | 58 | 99 | 1.71 | 99.0 |
| 2 | Miami (Florida) | 1 | 127 | 199 | 73 | 326 | 4.47 | 326.0 |
| 3 | Duke | 1 | 151 | 324 | 70 | 475 | 6.79 | 475.0 |
| 4 | Florida State | 2 | 177 | 495 | 131 | 672 | 5.13 | 336.0 |
| 5 | Boston College | 2 | 199 | 375 | 119 | 574 | 4.82 | 287.0 |
| 6 | Pittsburgh | 2 | 202 | 524 | 143 | 726 | 5.08 | 363.0 |
| 7 | North Carolina State | 2 | 243 | 508 | 144 | 751 | 5.22 | 375.5 |
| 8 | Virginia Tech | 2 | 246 | 504 | 145 | 750 | 5.17 | 375.0 |
| 9 | Syracuse | 2 | 284 | 431 | 125 | 715 | 5.72 | 357.5 |
| 10 | Louisville | 2 | 369 | 443 | 124 | 812 | 6.55 | 406.0 |
| 11 | Georgia Tech | 2 | 377 | 438 | 118 | 815 | 6.91 | 407.5 |
| 12 | North Carolina | 2 | 468 | 320 | 143 | 788 | 5.51 | 394.0 |
| 13 | Wake Forest | 2 | 561 | 306 | 160 | 867 | 5.42 | 433.5 |
| 14 | Virginia | 2 | 634 | 523 | 144 | 1157 | 8.03 | 578.5 |