2021 Atlantic Coast Conference Leaders Total Defense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Clemson | 4 | 281 | 827 | 265 | 1108 | 4.18 | 277.0 |
| 2 | Boston College | 4 | 666 | 690 | 271 | 1356 | 5.00 | 339.0 |
| 3 | Miami (Florida) | 4 | 584 | 773 | 284 | 1357 | 4.78 | 339.3 |
| 4 | North Carolina State | 4 | 624 | 736 | 284 | 1360 | 4.79 | 340.0 |
| 5 | Florida State | 4 | 438 | 996 | 291 | 1434 | 4.93 | 358.5 |
| 6 | Syracuse | 3 | 383 | 731 | 180 | 1114 | 6.19 | 371.3 |
| 7 | Louisville | 4 | 808 | 690 | 272 | 1498 | 5.51 | 374.5 |
| 8 | Pittsburgh | 4 | 282 | 1241 | 288 | 1523 | 5.29 | 380.8 |
| 9 | Virginia Tech | 4 | 555 | 1035 | 277 | 1590 | 5.74 | 397.5 |
| 10 | North Carolina | 4 | 634 | 1084 | 281 | 1718 | 6.11 | 429.5 |
| 11 | Wake Forest | 4 | 900 | 853 | 270 | 1753 | 6.49 | 438.3 |
| 12 | Virginia | 3 | 738 | 658 | 204 | 1396 | 6.84 | 465.3 |
| 13 | Georgia Tech | 4 | 789 | 1256 | 244 | 2045 | 8.38 | 511.3 |
| 14 | Duke | 4 | 1041 | 1385 | 295 | 2426 | 8.22 | 606.5 |