2021 Atlantic Coast Conference Leaders Total Defense - Games in October Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 3 | 407 | 983 | 217 | 1390 | 6.41 | 463.3 |
| 2 | Boston College | 4 | 985 | 630 | 251 | 1615 | 6.43 | 403.8 |
| 3 | Pittsburgh | 4 | 391 | 1070 | 257 | 1461 | 5.68 | 365.3 |
| 4 | North Carolina | 4 | 821 | 823 | 264 | 1644 | 6.23 | 411.0 |
| 5 | Florida State | 4 | 768 | 671 | 266 | 1439 | 5.41 | 359.8 |
| 6 | Clemson | 4 | 438 | 980 | 279 | 1418 | 5.08 | 354.5 |
| 7 | Virginia Tech | 4 | 885 | 843 | 285 | 1728 | 6.06 | 432.0 |
| 8 | North Carolina State | 4 | 534 | 1079 | 289 | 1613 | 5.58 | 403.3 |
| 9 | Duke | 4 | 706 | 1393 | 296 | 2099 | 7.09 | 524.8 |
| 10 | Louisville | 4 | 381 | 1269 | 298 | 1650 | 5.54 | 412.5 |
| 11 | Wake Forest | 4 | 1138 | 803 | 300 | 1941 | 6.47 | 485.3 |
| 12 | Virginia | 4 | 998 | 1134 | 304 | 2132 | 7.01 | 533.0 |
| 13 | Georgia Tech | 4 | 855 | 1341 | 320 | 2196 | 6.86 | 549.0 |
| 14 | Syracuse | 5 | 789 | 1016 | 347 | 1805 | 5.20 | 361.0 |