2021 Atlantic Coast Conference Leaders Rushing Defense - On 4th Down through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Boston College | 8 | 11 | -9 | -0.82 | 0 | 7 | 6 | 0 | 0 |
| 1 | Pittsburgh | 8 | 12 | -1 | -0.08 | 2 | 7 | 2 | 0 | 0 |
| 1 | Clemson | 6 | 9 | 0 | 0.00 | 0 | 6 | 3 | 0 | 0 |
| 1 | Syracuse | 8 | 12 | 10 | 0.83 | 0 | 6 | 7 | 0 | 0 |
| 1 | Wake Forest | 7 | 8 | 14 | 1.75 | 1 | 5 | 5 | 0 | 0 |
| 6 | Louisville | 8 | 9 | 19 | 2.11 | 0 | 11 | 4 | 1 | 0 |
| 6 | Florida State | 6 | 11 | 28 | 2.55 | 3 | 12 | 4 | 1 | 0 |
| 6 | North Carolina | 5 | 9 | 34 | 3.78 | 0 | 11 | 7 | 1 | 0 |
| 6 | Virginia Tech | 9 | 14 | 47 | 3.36 | 1 | 28 | 11 | 1 | 1 |
| 6 | Georgia Tech | 5 | 8 | 66 | 8.25 | 1 | 54 | 4 | 1 | 1 |
| 11 | Miami (Florida) | 7 | 10 | 38 | 3.80 | 1 | 40 | 5 | 2 | 2 |
| 11 | Duke | 4 | 6 | 52 | 8.67 | 1 | 21 | 5 | 2 | 1 |
| 13 | North Carolina State | 5 | 10 | 50 | 5.00 | 1 | 21 | 6 | 3 | 1 |
| 13 | Virginia | 8 | 12 | 89 | 7.42 | 0 | 38 | 10 | 3 | 2 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||