2021 Atlantic Coast Conference Leaders Rushing Defense - On 3rd Down, 10+ Yards To Go through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Duke | 6 | 12 | 71 | 5.92 | 1 | 44 | 1 | 1 | 1 |
| 2 | Pittsburgh | 13 | 25 | -8 | -0.32 | 0 | 23 | 1 | 2 | 1 |
| 2 | Miami (Florida) | 8 | 13 | 27 | 2.08 | 0 | 15 | 2 | 2 | 0 |
| 2 | Louisville | 7 | 15 | 34 | 2.27 | 0 | 20 | 1 | 2 | 1 |
| 2 | North Carolina | 8 | 14 | 48 | 3.43 | 0 | 11 | 1 | 2 | 0 |
| 6 | Syracuse | 12 | 22 | 12 | 0.55 | 0 | 13 | 3 | 3 | 0 |
| 6 | Clemson | 10 | 25 | 14 | 0.56 | 0 | 21 | 1 | 3 | 1 |
| 6 | Boston College | 8 | 15 | 43 | 2.87 | 1 | 21 | 0 | 3 | 1 |
| 6 | Virginia | 7 | 12 | 48 | 4.00 | 1 | 24 | 1 | 3 | 1 |
| 10 | Wake Forest | 8 | 19 | 49 | 2.58 | 0 | 23 | 2 | 4 | 1 |
| 10 | Georgia Tech | 10 | 17 | 56 | 3.29 | 0 | 14 | 2 | 4 | 0 |
| 12 | Florida State | 10 | 18 | 44 | 2.44 | 0 | 18 | 3 | 5 | 0 |
| 12 | North Carolina State | 10 | 20 | 60 | 3.00 | 1 | 17 | 4 | 5 | 0 |
| 14 | Virginia Tech | 9 | 18 | 143 | 7.94 | 0 | 21 | 4 | 7 | 1 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||