2021 Atlantic Coast Conference Leaders Rushing Defense - On 3rd Down, 4-6 Yards To Go through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Florida State | 10 | 23 | 12 | 0.52 | 0 | 10 | 7 | 1 | 0 |
| 1 | Boston College | 7 | 8 | 22 | 2.75 | 0 | 15 | 2 | 1 | 0 |
| 1 | North Carolina State | 7 | 9 | 25 | 2.78 | 0 | 21 | 4 | 1 | 1 |
| 1 | Duke | 6 | 9 | 49 | 5.44 | 1 | 40 | 1 | 1 | 1 |
| 1 | North Carolina | 11 | 26 | 75 | 2.88 | 0 | 16 | 9 | 1 | 0 |
| 6 | Pittsburgh | 9 | 14 | 19 | 1.36 | 0 | 16 | 5 | 2 | 0 |
| 6 | Clemson | 8 | 13 | 21 | 1.62 | 1 | 23 | 3 | 2 | 1 |
| 6 | Syracuse | 5 | 10 | 29 | 2.90 | 0 | 15 | 4 | 2 | 0 |
| 6 | Miami (Florida) | 10 | 17 | 45 | 2.65 | 1 | 30 | 5 | 2 | 2 |
| 6 | Virginia | 11 | 16 | 47 | 2.94 | 0 | 22 | 4 | 2 | 1 |
| 6 | Virginia Tech | 9 | 17 | 52 | 3.06 | 1 | 17 | 5 | 2 | 0 |
| 6 | Louisville | 8 | 17 | 54 | 3.18 | 3 | 35 | 4 | 2 | 1 |
| 6 | Georgia Tech | 8 | 12 | 64 | 5.33 | 2 | 31 | 3 | 2 | 1 |
| 6 | Wake Forest | 12 | 21 | 99 | 4.71 | 2 | 58 | 6 | 2 | 1 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||