2021 Big 12 Conference Leaders First Downs - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 4 | 52 | 43 | 13 | 108 | 27.0 |
| 2 | TCU | 4 | 48 | 36 | 9 | 93 | 23.3 |
| 2 | Oklahoma | 6 | 54 | 69 | 9 | 132 | 22.0 |
| 4 | West Virginia | 4 | 43 | 42 | 8 | 93 | 23.3 |
| 5 | Texas | 4 | 51 | 39 | 7 | 97 | 24.3 |
| 5 | Kansas State | 6 | 49 | 47 | 7 | 103 | 17.2 |
| 7 | Texas Tech | 5 | 49 | 65 | 5 | 119 | 23.8 |
| 7 | Iowa State | 5 | 49 | 59 | 5 | 113 | 22.6 |
| 9 | Kansas | 4 | 33 | 42 | 4 | 79 | 19.8 |
| 10 | Baylor | 5 | 56 | 53 | 3 | 112 | 22.4 |