2021 Iowa State Cyclones First Down Split Stats through 01/10/2022
| Split | G | Rush | Pass | Penalty | Total |
|---|---|---|---|---|---|
| All Games | 13 | 94 | 164 | 22 | 280 |
| at Home | 6 | 43 | 74 | 9 | 126 |
| on Road/Neutral Site | 7 | 51 | 90 | 13 | 154 |
| in Wins | 7 | 54 | 89 | 8 | 151 |
| in Losses | 6 | 40 | 75 | 14 | 129 |
| vs. Conference | 9 | 66 | 118 | 17 | 201 |
| vs. Non-Conference | 4 | 28 | 46 | 5 | 79 |
| vs. Ranked (AP) | 5 | 28 | 64 | 13 | 105 |
| vs. Unranked (AP) | 8 | 66 | 100 | 9 | 175 |
| vs. FBS (I-A) | 12 | 87 | 155 | 21 | 263 |
| vs. FCS (I-AA) | 1 | 7 | 9 | 1 | 17 |
| vs. FBS Winning | 7 | 38 | 96 | 16 | 150 |
| vs. FBS Non-Winning | 5 | 49 | 59 | 5 | 113 |
| vs. FBS Power 5 | 11 | 76 | 140 | 20 | 236 |
| vs. FBS non-Power 5 | 1 | 11 | 15 | 1 | 27 |
| in August/September | 4 | 33 | 51 | 8 | 92 |
| in October | 4 | 32 | 42 | 4 | 78 |
| in November | 4 | 25 | 62 | 9 | 96 |
| in December/January | 1 | 4 | 9 | 1 | 14 |