2021 Big 12 Conference Leaders First Downs - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | TCU | 3 | 31 | 37 | 9 | 77 | 25.7 |
| 2 | Oklahoma | 4 | 42 | 54 | 7 | 103 | 25.8 |
| 3 | Oklahoma State | 4 | 35 | 44 | 5 | 84 | 21.0 |
| 3 | Texas Tech | 4 | 37 | 39 | 5 | 81 | 20.3 |
| 3 | West Virginia | 4 | 32 | 43 | 5 | 80 | 20.0 |
| 3 | Iowa State | 4 | 28 | 46 | 5 | 79 | 19.8 |
| 7 | Texas | 3 | 32 | 27 | 4 | 63 | 21.0 |
| 7 | Kansas State | 4 | 47 | 31 | 4 | 82 | 20.5 |
| 9 | Kansas | 3 | 21 | 25 | 3 | 49 | 16.3 |
| 10 | Baylor | 4 | 58 | 29 | 2 | 89 | 22.3 |