2021 Big 12 Conference Leaders Interceptions - Games at Home Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Texas Tech | 6 | 3 | 78 | 1 | 0.50 |
| 2 | Oklahoma | 7 | 7 | 60 | 0 | 1.00 |
| 3 | TCU | 7 | 8 | 54 | 0 | 1.14 |
| 4 | Kansas | 6 | 3 | 50 | 1 | 0.50 |
| 5 | Oklahoma State | 7 | 4 | 48 | 0 | 0.57 |
| 6 | Baylor | 7 | 5 | 42 | 0 | 0.71 |
| 6 | Texas | 6 | 3 | 42 | 1 | 0.50 |
| 8 | Kansas State | 7 | 5 | 29 | 0 | 0.71 |
| 8 | West Virginia | 6 | 3 | 29 | 0 | 0.50 |
| 10 | Iowa State | 6 | 4 | 15 | 0 | 0.67 |